Peptide Nucleic Acids (PNAs)
Peptide nucleic acids (PNAs) have emerged as crucial tools in biomedical research due to their unique properties and versatile applications. PNAs are synthetic molecules that mimic DNA, but with a peptide backbone. This peptide backbone enhances their stability, resistance to degradation, and affinity for target sequences, making them ideal for a range of molecular biology techniques.
PNAs are extensively used for gene targeting, gene expression modulation, and diagnostics. They can specifically bind to DNA or RNA targets, preventing gene expression or enabling the detection of specific sequences. The outstanding potential of PNAs in applications such as antisense therapeutics, genome editing, and disease diagnosis has positioned them as valuable assets in advancing biomedical research.
Applications
Biosensors
SNP detection
FISH probes
Antisense and antigen therapy
antimicrobial agents
Hybridization experiments
Our offering
Custom PNA Synthesis
Synthesis scales of 30 nmol, 100 nmol up to µmoles
Purity either >70% or >90%
Hybrid structures of peptides and PNA possible
Our service
1. Initial consulting
We will evaluate your peptides on feasibility and physical properties to ensure high success rates. Also we can support you in designing your peptides according to your research aims.
2. Fast turn-around times
From order to delivery we can be as fast as 21 days, depending on the length, complexity, purity and other modifications. You will receive a delivery time estimate with your quote.
3. Continuous Feedback
You will receive regular updates on the status of your PNA project.
4. CoA and documentation
With your PNAs, you will receive a Certificate of Analysis and the complete analytical documentation, including HPLC and MS traces.
Peptide Nucleic Acids (PNAs) Modifications
If you cannot find a modification, please reach out to us. We will make it possible.
| Amino Acid |
|---|
| (L)-Phospho amino acids |
| (D)-Amino acids |
| Heavy isotope amino acids |
| 8-Amino-3,6-dioxaoctanoic acid |
| 6-Aminohexanoic acid |
| 2-Aminobutanoic acid |
| (L)-Lys(Ac)- |
| (L)-Glyco amino acids |
| (L)-Cys(Carboxamidomethyl)- |
| (L)-Arg(Me)2symm. |
| (L)-Arg(Me)2asymm. |
| (L)-Lys(Me)3– |
| (L)-Lys(Me)2– |
| (L)-Lys(Me)1– |
| Citrulline |
| Peptide | C-term | N-term | side-chain |
|---|---|---|---|
| 5/6-FAM | ✓ | ✓ | ✓ |
| 5-FAM | ✓ | ✓ | ✓ |
| 5/6-FITC | ✓ | ✓ | ✓ |
| 5-FITC | ✓ | ✓ | ✓ |
| 5/6-Tamra | ✓ | ✓ | ✓ |
| Biotin | ✓ | ✓ | ✓ |
| Dinitrophenyl (DNP) | ✓ | ✓ | ✓ |
| Dabsyl (Dabs) | ✓ | ✓ | ✓ |
| Dansyl (Dans) | ✓ | ✓ | ✓ |
| Methoxycoumarinacetyl (MCA) | ✓ | ✓ | ✓ |
| Maleimidopropionyl- | ✓ | ✓ | ✓ |
| Azidohexanoyl- | ✓ | ✓ | ✓ |
| Cy-5 | ✓ | ✓ | ✓ |
| Dyomics dyes | ✓ | ✓ | ✓ |
| Alexa Fluor® dyes | ✓ | ✓ | ✓ |
| 7-Amino-4-methylcoumarin (AMC) | ✓ | ✓ | ✓ |
| Chloromethylketone | ✓ | ✓ | ✓ |
| Aldehyde | ✓ | ✓ | ✓ |
| Lipopeptides | ✓ | ✓ | ✓ |
| Cyclopeptide | |||
| Sulfated peptides | ✓ | ✓ | ✓ |
| Conjugates |
|---|
| Keyhole Limpet Hemocyanin (KLH) |
| Bovine serum Albumine (BSA) |
| Ovalbumine |
| Immobilisation on Gold |
| Columnmatrix |
Frequently asked Questions
We recommend not to exceed 20 bases if possible, because the efficiency of the synthesis starts to drastically decrease upon further elongation. Longer sequences can increase the costs.
Yes, this is possible. We can attach several amino acids to your PNA, such as e.g. short CPP sequences.
Yes, this is in general possible through either coupling to the N-terminus of the PNA or through the introduction of C-terminal or N-terminal Lysine, which can be modified at the side-chain amino function.
We offer standard purities of >70% and >90% UV-purity after HPLC purification.
The standard scales are either 30 nmol, 100 nmol or 1 µmol. For larger amounts, please contact our staff via request@intavispeptides.com
The nucleobases are connected via a peptide backbone, that replaced the phosphate backbone.
Yes, PNA has a strong binding-affinity to DNA.
Order your peptides
Click order and a form will pop-up so you can enter your sequence directly. Alternatively upload a document listing your peptides or conjugates.