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Synthetic Peptides

Direct Quantification of Cytochromes P450 and Drug Transporters – A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture Lysates
Weiss, F. et al., Drug Metabolism and Disposition. 2018, dmd.117.078626

Study of the Humoral Immune Response towards HCV Genotype 4 Using a Bead-Based Multiplex Serological Assay
Filomena, A. et al., High-Throughput. 2017, 6, 15

Peptides in headlock – a novel high-affinity and versatile peptide-binding nanobody for proteomics and microscopy
Braun, M. B. et al., Scientific Reports. 2016, 6,

Analysis of Disease-Associated Protein Expression Using Quantitative Proteomics—Fibulin-5 Is Expressed in Association with Hepatic Fibrosis
Bracht, T. et al., Journal of Proteome Research. 2015, 14, 2278-2286

Non-radioactive protein lysine methyltransferase microplate assay based on reading domains.
Kudithipudi, S. et al., ChemMedChem, 2014, 9, 554-559

Difficulties in Generating Specific Antibodies for Immunohistochemical Detection of Nitrosylated Tubulins
Kamnev, A. et al., PLoS ONE. 2013, 8, e68168

Immunization with biodegradable nanoparticles efficiently induces cellular immunity and protects against influenza virus infection.
Knuschke, T. et al., J. Immunol., 2013, 190, 6221-6229

Peptide-based investigation of the Escherichia coli RNA polymerase σ70:core interface as target site.
Hüsecken, K. et al., Chem. Biol., 2013, 8, 758-766

Cytomegalovirus vectors violate CD8+ T Cell epitope recognition paradigms.
Hansen, S. G. et al., Science, 2013, 340, 6135ff

Egg cell–secreted EC1 triggers sperm cell activation during double fertilization.
Sprunck, S. et al., Science, 2012, 338, 1093-1097

Immunological impact of an additional early measles vaccine in Gambian children: Responses to a boost at 3 years.
Jainaba, N.-J. et al., Vaccine, 2012, 30, 2543-2550

Identification and Quantification of a New Family of Peptide Endocannabinoids (Pepcans) Showing Negative Allosteric Modulation at CB1 Receptors.
Bauer M. et al., J. Biol. Chem., 2012, 287, 36944-36967

Combining ultracentrifugation and peptide termini group-specific immunoprecipitation for multiplex plasma protein analysis.
Volk S. et al., Mol. Cell. Proteomics, 2012, 11, O111.015438

Targeting peptide termini, a novel immunoaffinity approach to reduce complexity in mass spectrometric protein identification.
Hoeppe S. et al., Mol. Cell. Proteomics, 2011, 10, M110.00285

Cytomegalovirus-Specific T Cell Immunity Is Maintained in Immunosenescent Rhesus Macaques
Cicin-Sain, L. et al., The Journal of Immunology. 2011, 187, 1722-1732

The Dnmt3a PWWP Domain Reads Histone 3 Lysine 36 Trimethylation and Guides DNA Methylation
Dhayalan, A. et al., Journal of Biological Chemistry. 2010, 285, 26114-26120

High titer HIV-1 V3-specific antibodies with broad reactivity but low neutralizing potency in acute infection and following vaccination.
Davis, K. L. et al., Virology, 2009, 387, 414-426

Characterization of PrEST-based antibodies towards human Cytokeratin-17.
Larsson, K. et al., J. Immunol. Methods, 2009, 342, 20-32

High levels of subgenomic HCV plasma RNA in immunosilent infections.
Bernardin, F. et al., Virology, 2007, 365, 446-456

Splicing Segregation: The Minor Spliceosome Acts outside the Nucleus and Controls Cell Proliferation.
König, H. et al., Cell, 2007, 131, 718-729

Synthetic access to spacer-linked 3,6-diamino-2,3,6-trideoxy-α-D-glucopyranosides-potential aminoglycoside mimics for the inhibition of the HIV-1 TAR-RNA/Tat-peptide complex.
Jöge, T. et al., Carbohydr. Res., 2007, 342, 1704-1714

The Cell Penetrating Peptides pVEC and W2-pVEC Induce Transformation of Gel Phase Domains in Phospholipid Bilayers without Affecting Their Integrity.
Herbig, M. E. et al., Biochemistry, 2006, 45, 3598-3609

Frequency analysis of HLA-B7-restricted Epstein-Barr virus-specific cytotoxic T lymphocytes in patients with multiple sclerosis and healthy controls.
Gronen, F. et al., J. Neuroimmunol., 2006, 180, 185-192

Membrane Surface-Associated Helices Promote Lipid Interactions and Cellular Uptake of Human Calcitonin-Derived Cell Penetrating Peptides.
Herbig, M. E. et al., Biophys. J., 2005, 89, 4056-4066

Bilayer interaction and localization of cell penetrating peptides with model membranes:
A comparative study of a human calcitonin (hCT)-derived peptide with pVEC and pAntp(43–58).
Herbig, M. E. et al., Biochim. biophys. Acta, 2005, 1712, 197-211

Custom Peptide Sets
Peptide Libraries

Identification of short terminal motifs enriched by antibodies using peptide mass fingerprinting.
Planatscher, H. et al., Bioinformatics, 2014, DOI: 10.1093/bioinformatics/btu009.

A large synthetic peptide and phosphopeptide reference library for mass spectrometry–based proteomics.
Marx, H. et al., Nat. Biotechnol., 2013, 31, 557-564.

Parallel synthesis and splicing redirection activity of cell-penetrating peptide conjugate libraries of a PNA cargo.
Deuss, P. J. et al., Org. Biomol. Chem., 2013, 11, 7621-7630.

The SH2 Domain Interaction Landscape.
Tinti, M. et al., Cell Reports, 2013, 3,1293-1305.

Natural immunity to pluripotency antigen OCT4 in humans.
Dhodapkar, K. M. et al., Proc. Nat. Ac. Sci., 2010, 107, 8718-8723.

The phosphotyrosine interactome of the insulin receptor family and its substrates IRS-1 and IRS-2.
Hanke, S. et al., Mol. Cell. Proteomics, 2009, 8, 519-534.

A versatile strategy to define the phosphorylation preferences of plant protein kinases and screen for putative substrates.
Vlad, F. et al., Plant J., 2008, 55, 104-117.

Probing the substrate specificity of the dengue virus type 2 NS3 serine protease by using internally quenched fluorescent peptides.
Niyomrattanakit, P. et al., Biochem. J., 2006, 397, 203–211

SPOT-Membrane Peptide Arrays

Screening and optimizing ontimicrobial Peptides by using SPOT-Synthesis. López-pérez P. M. et al., Front. Chem., 2017, 5, doi:10.3389/fchem.2017.00025.

Investigation of the network of preferred interactions in an artificial coiled-coil association using the peptide array technique
Araghi, R. R. et al., Beilstein Journal of Organic Chemistry. 2012, 8, 640-649

Synthetic peptide arrays for investigating protein interaction domains
Volkmer, R. et al., FEBS Letters. 2012, 586, 2780-2786

The Plk1-dependent phosphoproteome of the early mitotic spindle.
Santamaria, A. et al., Mol. Cell Proteomics, 2011, 10, M110.004457

Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation.
Zegerman, P. and Diffley, J. F. X., Nature, 2010, 467, 474-478

Identification of High-Affinity PB1-Derived Peptides with Enhanced Affinity to the PA Protein of Influenza A Virus Polymerase
Wunderlich, K. et al., Antimicrobial Agents and Chemotherapy. 2010, 55, 696-702

Peptide Microarrays: Methods and Protocols. Cretich, M., & Chiari, M. Springer, 2009 

Synthesis and Application of Peptide Arrays: Quo Vadis SPOT Technology
Volkmer, R., ChemBioChem. 2009, 10, 1431-1442

Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase.
Kiely, P. A. et al., J. Biol. Chem., 2009, 284, 20263-20274

Peptide arrays on cellulose support: SPOT synthesis, a time and cost efficient method for synthesis of large numbers of peptides in a parallel and addressable fashion.
Hilpert, K. et al., Nature Protocols, 2, 2007, ,1333-1349.

Cellulose-bound peptide arrays: preparation and applications
Hilpert, K. et al., Biotechnology and Genetic Engineering Reviews. 2007, 24, 31-106

Using peptide arrays to define nuclear carrier binding sites on nucleoporins
Cushman, I. et al., Methods. 2006, 39, 329-341

Analysis of Protein Interactions with Immobilized Peptide Arrays Synthesized on Membrane Supports
Frank, R. et al., Cold Spring Harbor Protocols. 2006, 2006, pdb.prot4566-pdb.prot456

Applying the SPOT peptide synthesis procedure to the study of protein tyrosine phosphatase substrate specificity: probing for the heavenly match in vitro
ESPANEL, X. et al., Methods. 2005, 35, 64-72

Kombinatorische SPOT-Synthese neuer S-Glycopeptide als Oligosaccharidmimikry zur Untersuchung von Kohlenhydrat-Protein-Wechselwirkungen
Schips, C., 2005,

The SPOT-synthesis technique. Synthetic peptide arrays on membrane supports – principles and applications.
Frank, R., J. Immunol. Meth., 267, 13 – 26 (2002)

Peptide Arrays on Membrane Supports – Synthesis and Applications.
Joachim Koch and Michael Mahler (Eds.), Springer – Berlin Heidelberg New York 2002, ISBN 3-450-42532-2

Spot synthesis: an easy technique for the positionally addressable, parallel chemical synthesis on a membrane support.
Frank, R. Tetrahedron, 1992, 48, 9217-9232.

The simultaneous multiple production of solution phase peptides; assessment of the Geysen Method of simultaneous peptide synthesis.
Bray, A. et al., Tet. Lett., 1990, 31, 5811-5814.

CelluSpots Custom Peptide Arrays

The Mesenchymal Precursor Cell Marker Antibody STRO-1 Binds to Cell Surface Heat Shock Cognate 70
Fitter, S. et al., STEM CELLS. 2017, 35, 940-951

Application of dual reading domains as novel reagents in chromatin biology reveals a new H3K9me3 and H3K36me2/3 bivalent chromatin state
Mauser, R. et al., Epigenetics & Chromatin. 2017, 10,

Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission
Maric, H. M. et al., Nature chemical biology. 2016,

Highly homologous proteins exert opposite biological activities by using different interaction interfaces
Amir, A. I. et al., Scientific Reports. 2015, 5,

B cell epitopes on infliximab identified by oligopeptide microarray with unprocessed patient sera
Homann, A. et al., Journal of Translational Medicine. 2015, 13,

Identifying Protein-protein Interaction Sites Using Peptide Arrays
Amartely, H. et al., Journal of Visualized Experiments. 2014,

Design of affinity peptides from natural protein ligands: A study of the cardiac troponin complex
Chandra, D. et al., Biopolymers. 2014, 102, 97-106

Development of Bispecific Molecules for the In Situ Detection of Protein-Protein Interactions and Protein Phosphorylation
van Dieck, J. et al., Chemistry & Biology. 2014, 21, 357-368

Secretion and Immunogenicity of the Meningioma-Associated Antigen TXNDC16
Harz, C. et al., The Journal of Immunology. 2014, 193, 3146-3154

Application of histone modification-specific interaction domains as an alternative to antibodies
Kungulovski, G. et al., Genome Research. 2014, 24, 1842-1853

ChIP-less analysis of chromatin states
Su, Z. et al., Epigenetics & chromatin. 2014, 7, 7

Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1
Tamir, S. et al., Proceedings of the National Academy of Sciences. 2014, 111, 5177-5182

Mapping of epitopes recognized by antibodies induced by immunization of mice with PspA and PspC.
Vadesilho, C. F. M. et al., Clin. Vaccine Immunol., 2014, 21, 940-948.

The scaffold protein MUPP1 regulates odorant-mediated signaling in olfactory sensory neurons.
Baumgart, S. et al., J. Cell Sci., 2014, 127, 2518-2527.

Structure–activity relationship studies using peptide arrays: the example of HIV-1 Rev–integrase interaction.
Gabizon, R. et al., Med. Chem. Commun., 2013, 4, 252-259.

Characterization of the translocation-competent complex between the Helicobacter pylori oncogenic protein CagA and the accessory protein CagF.
Bonsor, D. A. et al, J. Biol. Chem., 2013, 288, 32897-32909.

Mapping the Vif–A3G interaction using peptide arrays: A basis for anti-HIV lead peptides.
Reingewertz, T. H. et al., Bioorg. Med. Chem., 2013, 21, 3523-3532.

Peptide Arrays for Development of PDGFRβ Affine Molecules.
Marr, A. et al., Mol. Imaging Biol., 2013, 15, 391-400.

Design of peptide affinity ligands for S-protein: a comparison of combinatorial and de novo design strategies
Chandra, D. et al., Molecular Diversity. 2013, 17, 357-369

Highly sensitive detection of protein phosphorylation by using improved Phos-tag Biotin.
Kinoshita, E. et al., Proteomics, 2012, 12 , 932-937.

Lamin B receptor recognizes specific modifications of histone H4 in heterochromatin formation.
Hirano, Y. et al., J. Biol. Chem.,2012, 287, 42654-42663.

The SET8 H4K20 protein lysine methyltransferase has a long recognition sequence covering seven amino acid residues.
Kudithipudi, S. et al., Biochemie, 2012, 94, 2212-2218.

Multivalent Recognition of Histone Tails by the PHD Fingers of CHD5.
Oliver, S. S. et al., Biochemistry, 2012, 51, 6534-6544.

Molecular Basis of the Interaction between Proapoptotic Truncated BID (tBID) Protein and Mitochondrial Carrier Homologue 2 (MTCH2) Protein: Key Players in Mitochondrial Pathway.
Katz, C. et al., J. Biol. Chem., 2012, 287, 15016-15023.

TheTomato yellow leaf curl virus(TYLCV) V2 protein interacts with the host papain-like cysteine protease CYP1
Bar-Ziv, A. et al., Plant Signaling & Behavior. 2012, 7, 983-989

Probing subunit-subunit interactions in the yeast vacuolar ATPase by peptide arrays
Parsons, L. S. et al., PloS one. 2012, 7, e46960

Secreted Kinase Phosphorylates Extracellular Proteins That Regulate Biomineralization
Tagliabracci, V. S. et al., Science. 2012, 336, 1150-1153

Detailed specificity analysis of antibodies binding to modified histone tails with peptide arrays.
Bock, I. et al., Epigenetics, 2011, 6, 256-263

Stomatal Closure by Fast Abscisic Acid Signaling Is Mediated by the Guard Cell Anion Channel SLAH3 and the Receptor RCAR1.
Geiger, D. et al., Sci. Signal, 2011, 4, ra32

The ATRX-ADD domain binds to H3 tail peptides and reads the combined methylation state of K4 and K9.
Dhayalan, A. et al., Hum. Mol. Genet., 2011, 20, 2195-2203

Voltage-dependent anion channel 1-based peptides interact with Bcl-2 to prevent antiapoptotic activity.
Arbel, N. et al., J. Biol. Chem., 2010, 285, 6053-6062

The IKK complex contributes to the induction of autophagy.
Criollo, A. et al., EMBO J., 2010, 293, 619-631

Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail.
Zhang, Y. et al; Nucleic Acids Res., 2010, 38, 4246-4253

Modulation of cell spreading and cell-substrate adhesion dynamics by dystroglycan
Thompson, O. et al., Journal of Cell Science. 2009, 123, 118-127

Olfactory receptor signaling is regulated by the post-synaptic density 95, Drosophila discs large, zona-occludens 1 PDZ scaffold multi-PDZ domain protein 1.
Dooley, R. et al., FEBS J., 2009, 276, 7279-7290

Activity of guard cell anion channel SLAC1 is controlled by drought-stress signaling kinase-phosphatase pair.
Geiger, D. et al., Proc. Natl. Acad. Sci. USA, 2009, 106, 21425-21430.

Synergistic proapoptotic effects of the two tyrosine kinase inhibitors pazopanib and lapatinib on multiple carcinoma cell lines.
Olaussen, K. A. et al., Oncogene, 2009, 28, 4249–4260

A substrate peptide for the FLT3 receptor tyrosine kinase.
Boehmer, F.-D. et al., Br. J. Haematol., 2009, 144, 127-130

Defining the specificity space of the human SRC homology 2 domain.
Huang, H. et al., Mol. Cell Proteomics, 2008, 74, 768-784

Analysis of EphA4 receptor tyrosine kinase substrate specificity using peptide-based arrays.
Warner, N. et al., FEBS J., 2008, 275, 2561-2573

Molecular basis of the interaction between the antiapoptotic Bcl-2 family proteins and the proapoptotic protein ASPP2.
Katz, C. et al., Proc. Natl. Acad. Sci. USA, 2008, 105, 12277-12282

Synthesis Resin

Biselectivity of isoDGR Peptides for Fibronectin Binding Integrin Subtypes α5β1 and αvβ6: Conformational Control through Flanking Amino Acids.
Bochen, A. et al., J. Med. Chem., 2013, 56, 1509-1519.

A Periodate-Cleavable Linker for Functional Proteomics under Slightly Acidic Conditions: Application for the Analysis of Intracellular Aspartic Proteases.
Maurer, A. et al., J. Proteome Res., 2013, 12, 199−207.

Interface Immobilization Chemistry of cRGD‐based Peptides Regulates Integrin Mediated Cell Adhesion.
Pallarola, D. et al., Adv. Funct. Mater., 2013, doi: 10.1002/adfm.201302411.

Ethyl substituted coumarin-4-yl derivatives as photoremovable protecting groups for amino acids with improved stability for SPPS.
Weiss, S. et al., J. Photochem. Photobiol. A: Chemistry, 2012, 241, 52-57.

Guiding plant virus particles to integrin-displaying cells.
Hovlid, M. L. et al., Nanoscale, 2012, 4, 3698-3705

CyLoP-1: A Novel Cysteine-Rich Cell-Penetrating Peptide for Cytosolic Delivery of Cargoes.
Jha, D. et al., Bioconjugate Chem., 2011, 22, 319-328

Improving Oral Bioavailability of Peptides by Multiple N-Methylation: Somatostatin Analogues.
Biron, E. et al., Angew. Chem. Int. Ed.,2008, 47, 2595–2599

In situ assembly of macromolecular complexes triggered by light.
Grunwald, C. et al., Proc. Natl. Acad. Sci. USA, 2010, 107, 6146-6151

Conformational Preference and Potential Templates of N-Methylated Cyclic Pentaalanine Peptides.
Chatterjee, J. et al., Chem. Eur. J., 2008, 14, 1508-1517

Titanium dioxide as a chemo-affinity solid phase in offline phosphopeptide chromatography prior to HPLC-MS/MS analysis.
Mazanek, M. et al., Nat. Protoc., 2007, 2, 1059-1069

Triphosgene as highly efficient reagent for the solid-phase coupling of N-alkylated amino acids—total synthesis of cyclosporin O.
Thern, B. et al., Tetr. Lett., 2002, 43, 5013-5016

Total Synthesis of the Nematicidal Cyclododecapeptide Omphalotin A by Using Racemization-Free Triphosgene-Mediated Couplings in the Solid Phase.
Thern, B. et al., Angew. Chem. Int. Ed., 2002, 41, 2307-2309

An efficient Fmoc strategy for the rapid synthesis of peptide para-nitroanilides.
Abbenante, G. et al., Lett. Pept. Sci., 2000, 7, 347-351

Multimeric Cyclic RGD Peptides as Potential Tools for Tumor Targeting: Solid-Phase Peptide Synthesis and Chemoselective Oxime Ligation.
Thumshirn, G. et al., Chem. Eur. J., 2003, 9,2717-2725

Glycosylated RGD-Containing Peptides: Tracer for Tumor Targeting and Angiogenesis Imaging with Improved Biokinetics.
Haubner, R. et al., J. Nucl. Med., 2001, 42, 326-336

Combined solid phase and solution synthesis of the fully protected segment 74-99 of HIV 1-protease with the application of a new trityl-linker.
Henkel, B. et al., Z. Naturforsch. B: Chem. Sci., 1996, 51, 1339-1346

Bayer, E., Clausen, N., Goldammer, C., Henkel, B., Rapp, W., Zhang, L. in Peptides: Chemistry, Structure & Biology, 13th Am. Pept. Symp. (Eds.: R. S. Hodges, J. A. Smith), ESCOM, Leiden, 1994, 156-158

 

CelluSpots Kinase Substrate Arrays

Highly sensitive detection of protein phosphorylation by using improved Phos-tag Biotin.
Kinoshita, E. et al., Proteomics, 2012, 12 , 932-937.

The IKK complex contributes to the induction of autophagy.
Criollo, A. et al., EMBO J., 2010, 293, 619-631.

Synergistic proapoptotic effects of the two tyrosine kinase inhibitors pazopanib and lapatinib on multiple carcinoma cell lines.
Olaussen, K. A. et al., Oncogene, 2009, 28, 4249–4260.

A substrate peptide for the FLT3 receptor tyrosine kinase.
Boehmer, F.-D. et al., Br. J. Haematol., 2009, 144, 127-130.

Analysis of EphA4 receptor tyrosine kinase substrate specificity using peptide-based arrays.
Warner, N. et al., FEBS J., 2008, 275, 2561-2573.

A versatile strategy to define the phosphorylation preferences of plant protein kinases and screen for putative substrates.
Vlad, F. et al., Plant J., 2008, 55, 104-117.