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Als etablierter Akteur im Bereich Biotechnologie und Pharmazie sind wir auf die kundenspezifische Peptidsynthese spezialisiert und bedienen vielfältige Kundschaft weltweit. Unser Anspruch auf höchste Qualität zeigt sich in unseren Produkten sowie in der Anerkennung innerhalb der wissenschaftlichen Gemeinschaft. Unsere Peptide werden regelmäßig in wissenschaftlichen Arbeiten verwendet und zitiert. Die Referenzen zu unseren Produkten finden Sie unter folgenden Kategorien: Peptidbibliotheken, Synthesesäulen, SPOT-Membran-Peptidarrays, Kundenspezifische Peptidsets, CelluSpots Kundenspezifische Peptidarrays, CelluSpots Kinase-Substratarrays und Synthetische Peptide. Wir freuen uns über diese herausragend postive Resonanz.

Introduction to GMP and Its Importance in Peptide Production

Exploring the transformative impact of Good Manufacturing Practices (GMP) on peptide production, ensuring safety, efficacy, and the highest quality standards in pharmaceuticals. This article investigates the critical role of Good Manufacturing Practices (GMP) in enhancing the safety, quality, and consistency of peptide production for therapeutic and research applications.

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How to Ensure Regulatory Compliance in Peptide Manufacturing

This article is about ensuring regulatory compliance in peptide manufacturing. It explains the essential steps and best practices that peptide manufacturers need to follow to guarantee the safety, efficacy, and quality of their products.

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Ensuring GMP Peptide Quality: Storage & Packaging Best Practices

This article explores the critical role of storage and packaging in maintaining the integrity and efficacy of GMP peptides. Researchers delve into the impact of material selection, lyophilization, and temperature control on peptide stability, offering valuable insights for researchers and clinicians working with these vital biomolecules.

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Quality Control and Assurance in GMP Peptide Production

This informative piece explores the critical role of Quality Control (QC) and Quality Assurance (QA) in guaranteeing the safety and effectiveness of peptides used in research and therapy. By following Good Manufacturing Practice (GMP) standards, manufacturers ensure production adheres to rigorous testing protocols and consistent quality.

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Peptide Design and Synthesis under GMP Conditions

Discover the intricate world of peptide therapeutics, where meticulous design and synthesis under Good Manufacturing Practice standards ensure drugs are safe, effective, and of the highest quality. Explore how these processes combine scientific expertise and strict regulatory compliance to meet both therapeutic potential and patient expectations.

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Neoantigen Personalized Cancer Vaccines - an overview

Neoantigen Personalized Cancer Vaccines are promising to change the therapy of cancer by allowing more effective treatment with fewer adverse events. This article will provide an overview of the science behind the technology and how Neoantigen Cancer Vaccines can be developed.

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Custom Peptide Synthesis - an overview

Custom peptide synthesis, driven by advancements in technology, has revolutionized the field of life sciences. The employment of solid-phase peptide synthesis, along with automation, has allowed researchers to efficiently synthesize peptides with high purity and yields.

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Mastering Growth and Quality – GMP Grade Peptides

Technological advances in next generation sequencing, cell editing and peptide synthesis have made personalized medicine possible. But to make it available to the general public, clinical trials are needed. Providing GMP-grade peptides for clinical trials is the challenge Intavis Peptide Services is tackling.

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Veröffentlichungen

A T-cell antigen atlas for meningioma: novel options for immunotherapy

Medici, G. et al., Acta Neuropathologica. 2023, 146, 173–190

Co-chaperone BAG3 enters autophagic pathway via its interaction with microtubule associated protein 1 light chain 3 beta

Körschgen, H. et al., Traffic. 2023

T cell immunity ameliorates COVID-19 disease severity and provides post-exposure prophylaxis after peptide-vaccination, in Syrian hamsters

Somogyi, E. et al., Front. Immunol.. 2023, 14, 1111629

Overexpression of the mitochondrial anti-viral signaling protein, MAVS, in cancers is associated with cell survival and inflammation

Trishna, S. et al., Molecular Therapy-Nucleic Acids. 2023, 33, P713-732

Resolving Isomeric Posttranslational Modifications Using a Biological Nanopore as a Sensor of Molecular Shape

Ensslen, T. et al., J. Am. Chem. Soc. 2022, 144, 35, 16060–16068

Mapping the sequence specificity of heterotypic amyloid interactions enables the identification of aggregation modifiers

Louros, N. et al., Nat Commun. 2022, 13, 1351

Transcriptomic and genomic studies classify NKL54 as a histone deacetylase inhibitor with indirect influence on MEF2-dependent transcription

Minisini, M. et al., Nucleic Acids Research. 2022, 50, 2566–2586

MIA3/TANGO1 enables efficient secretion by constraining COPII vesicle budding

McCaughey, J. et al., bioRxiv. 2021

Epitope-specific antibody responses differentiate COVID-19 outcomes and variants of concern

Voss, C. et al., JCI Insight. 2021, 6(13), e148855

Characterization of CD8 T Cell-Mediated Mutations in the Immunodominant Epitope GP33-41 of Lymphocytic Choriomeningitis Virus

Smyth, M. et al., Front. Immunol. 2021, 12, 638485

Quantitative consequences of protein carriers in immunopeptidomics and tyrosine phosphorylation MS2 analyses

Stofer, LE. et al., Mol Cell Proteomics. 2021, 20, 100104

The 14-3-3/SLP76 protein–protein interaction in T-cell receptor signalling: a structural and biophysical characterization

Soini, L. et al., FEBS Lett. 2021, 595, 404-414

Phospho-Form Specific Substrates of Protein Kinase B (AKT1)

McKenna, M. et al., Front. Bioeng. Biotechnol. 2021, 8, 619252

CCR5 tyrosine sulfation heterogeneity generates cell surface receptor subpopulations with different ligand binding properties

Scurci, I. et al., Biochimica et Biophysica Acta (BBA) – General Subjects. 2021, 1865, 129753

Tris(hydroxymethyl)aminomethane Compatibility with N-Hydroxysuccinimide Ester Chemistry: Biotinylation of Peptides and Proteins in TRIS Buffer

Kratzer, U. et al. Bioconjug Chem. 2021, 32(9): 1960-1965

A Simple, Cheap and Fast Method for Calculation of Peptides Uo be used as Ligands in Affinity Chromatography or in Other Applications in Biotech and Pharma Industry

Havryliuk, SP. et al., Am J Pharmacol Ther. 2020, 4(1), 007-018

Both metal-chelating and free radical-scavenging synthetic pentapeptides as efficient inhibitors of reactive oxygen species generation†

Csire, G. et al., Metallomics. 2020, 12, 1220–1229

Influenza A viruses limit NLRP3-NEK7-complex formation and pyroptosis in human macrophages

Boal-Carvalho, I. et al., EMBO Reports. 2020, 21, e50421

Multiplexed relative and absolute quantitative immunopeptidomics reveals MHC I repertoire alterations induced by CDK4/6 inhibition

Stopfer, L.E. et al., Nature Communications. 2020, 11, Article number: 2760

Structure-based machine-guided mapping of amyloid sequence space reveals uncharted sequence clusters with higher solubilities

Louros, N. et al., Nature Communications. 2020, 11, Article number: 3314

Monitoring Dicer-Mediated miRNA-21 Maturation and Ago2 Loading by a Dual-Colour FIT PNA Probe Set

Loibl, N. et al., ChemBioChem. 2020, 21, 2527-2532

Synthesis of Lactam-Bridged and Lipidated Cyclo-Peptides as Promising Anti-Phytopathogenic Agents

Vasco, A.V. et al., Molecules. 2020, 25(4), 811

Strategy for Development of Site-Specific Ubiquitin Antibodies

van Kruijsbergen, I. et al., Front. Chem. 2020, 8, 111

Genetic Inactivation of Two-Pore Channel 1 Impairs Spatial Learning and Memory

Mallmann, RT. et al., Behavior Genetics. 2020, 50, 401–410

Optimized combinatorial pMHC class II multimer labeling for precision immune monitoring of tumor-specific CD4 T cells in patients

Rockinger, GA. et al., J Immunother Cancer. 2020, 8(1), e000435

Identification of immunodominant linear epitopes from SARS-CoV-2 patient plasma

Farrera-Soler, L. et al., PLoS ONE. 2020, 15(9), e0238089

IgE Epitope Profiling for Allergy Diagnosis and Therapy – Parallel Analysis of a Multitude of Potential Linear Epitopes Using a High Throughput Screening Platform

Krause, T. et al., Front. Immunol. 2020, 11, 565243

A Combined Strategy to Improve the Development of a Coral Antivenom Against Micrurus spp.

de Castro , KLP. et al., Front. Immunol. 2019, 10, 2422

Sterol transfer by atypical cholesterol-binding NPC2 proteins in coral-algal symbiosis

Hambleton, E.A. et al., eLife. 2019, 8, e43923

Global profiling of myristoylation in Toxoplasma gondii reveals key roles for lipidation in CDPK1 and MIC7 function

Broncel, M. et al., bioRxiv. 2019

Involvement of the Adhesion GPCRs Latrophilins in the Regulation of Insulin Release

Röthe, J. et al., Cell Reports. 2019, 26, 1573-1584.e5

Surface Loops in a Single SH2 Domain Are Capable of Encoding the Spectrum of Specificity of the SH2 Family*[S]

Liu, H. et al., MCP. 2019, 18, 372-382

A biophysical study of the interactions between the antimicrobial peptide indolicidin and lipid model systems

Nielsen, J.E. et al., Biochimica et Biophysica Acta (BBA) – Biomembranes. 2019, 1861, 1355-1364

Role of pentamer complex-specific and IgG subclass 3 antibodies in HCMV hyperimmunoglobulin and standard intravenous IgG preparations

Schampera, M.S. et al., Medical Microbiology and Immunology. 2019, 208, 69–80

IFIT5 Participates in the Antiviral Mechanisms of Rainbow Trout Red Blood Cells

Chico, V. et al., Front. Immunol. 2019, 10, 613

Direct Quantification of Cytochromes P450 and Drug Transporters – A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture Lysates

Weiss, F. et al., Drug Metabolism and Disposition. 2018, dmd.117.078626

Study of the Humoral Immune Response towards HCV Genotype 4 Using a Bead-Based Multiplex Serological Assay

Filomena, A. et al., High-Throughput. 2017, 6, 15

Peptides in headlock – a novel high-affinity and versatile peptide-binding nanobody for proteomics and microscopy

Braun, M. B. et al., Scientific Reports. 2016, 6,

Analysis of Disease-Associated Protein Expression Using Quantitative Proteomics—Fibulin-5 Is Expressed in Association with Hepatic Fibrosis

Bracht, T. et al., Journal of Proteome Research. 2015, 14, 2278-2286

Non-radioactive protein lysine methyltransferase microplate assay based on reading domains.

Kudithipudi, S. et al., ChemMedChem, 2014, 9, 554-559

Difficulties in Generating Specific Antibodies for Immunohistochemical Detection of Nitrosylated Tubulins

Kamnev, A. et al., PLoS ONE. 2013, 8, e68168

Immunization with biodegradable nanoparticles efficiently induces cellular immunity and protects against influenza virus infection.

Knuschke, T. et al., J. Immunol., 2013, 190, 6221-6229

Peptide-based investigation of the Escherichia coli RNA polymerase σ70:core interface as target site.

Hüsecken, K. et al., Chem. Biol., 2013, 8, 758-766

Cytomegalovirus vectors violate CD8+ T Cell epitope recognition paradigms.

Hansen, S. G. et al., Science, 2013, 340, 6135ff

Egg cell–secreted EC1 triggers sperm cell activation during double fertilization.

Sprunck, S. et al., Science, 2012, 338, 1093-1097

Immunological impact of an additional early measles vaccine in Gambian children: Responses to a boost at 3 years.

Jainaba, N.-J. et al., Vaccine, 2012, 30, 2543-2550

Identification and Quantification of a New Family of Peptide Endocannabinoids (Pepcans) Showing Negative Allosteric Modulation at CB1 Receptors.

Bauer M. et al., J. Biol. Chem., 2012, 287, 36944-36967

Combining ultracentrifugation and peptide termini group-specific immunoprecipitation for multiplex plasma protein analysis.

Volk S. et al., Mol. Cell. Proteomics, 2012, 11, O111.015438

Targeting peptide termini, a novel immunoaffinity approach to reduce complexity in mass spectrometric protein identification.

Hoeppe S. et al., Mol. Cell. Proteomics, 2011, 10, M110.00285

Cytomegalovirus-Specific T Cell Immunity Is Maintained in Immunosenescent Rhesus Macaques

Cicin-Sain, L. et al., The Journal of Immunology. 2011, 187, 1722-1732

The Dnmt3a PWWP Domain Reads Histone 3 Lysine 36 Trimethylation and Guides DNA Methylation

Dhayalan, A. et al., Journal of Biological Chemistry. 2010, 285, 26114-26120

High titer HIV-1 V3-specific antibodies with broad reactivity but low neutralizing potency in acute infection and following vaccination.

Davis, K. L. et al., Virology, 2009, 387, 414-426

Characterization of PrEST-based antibodies towards human Cytokeratin-17.

Larsson, K. et al., J. Immunol. Methods, 2009, 342, 20-32

High levels of subgenomic HCV plasma RNA in immunosilent infections.

Bernardin, F. et al., Virology, 2007, 365, 446-456

Splicing Segregation: The Minor Spliceosome Acts outside the Nucleus and Controls Cell Proliferation.

König, H. et al., Cell, 2007, 131, 718-729

Synthetic access to spacer-linked 3,6-diamino-2,3,6-trideoxy-α-D-glucopyranosides-potential aminoglycoside mimics for the inhibition of the HIV-1 TAR-RNA/Tat-peptide complex.

Jöge, T. et al., Carbohydr. Res., 2007, 342, 1704-1714

The Cell Penetrating Peptides pVEC and W2-pVEC Induce Transformation of Gel Phase Domains in Phospholipid Bilayers without Affecting Their Integrity.

Herbig, M. E. et al., Biochemistry, 2006, 45, 3598-3609

Frequency analysis of HLA-B7-restricted Epstein-Barr virus-specific cytotoxic T lymphocytes in patients with multiple sclerosis and healthy controls.

Gronen, F. et al., J. Neuroimmunol., 2006, 180, 185-192

Membrane Surface-Associated Helices Promote Lipid Interactions and Cellular Uptake of Human Calcitonin-Derived Cell Penetrating Peptides.

Herbig, M. E. et al., Biophys. J., 2005, 89, 4056-4066

Bilayer interaction and localization of cell penetrating peptides with model membranes: A comparative study of a human calcitonin (hCT)-derived peptide with pVEC and pAntp(43–58).

Herbig, M. E. et al., Biochim. biophys. Acta, 2005, 1712, 197-211

A STAT3 protein complex required for mitochondrial mRNA stability and cancer

Fernando, C. D., Jayasekara, W. S. N., Inampudi, C., Kohonen-Corish, M. R., Cooper, W. A., Beilharz, T. H., ... & Gough, D. J. (2023). Cell Reports, 42(9).

A fuzzy complex in the negative arm regulates circadian clock robustness

Hurley, J. et al., Research Square. 2022

Pea (Pisum sativum) allergy in children: Pis s 1 is an immunodominant major pea allergen and presents IgE binding sites with potential diagnostic value

Popp, J. et al., Clinical & Experimental Allergy. 2020, 50, 625-635

Targeted disruption of Kv2.1-VAPA association provides neuroprotection against ischemic stroke in mice by declustering Kv2.1 channels

SCHULIEN, A.J. et al., SCIENCE ADVANCES. 2020, 6, No. 27

Highly sensitive detection of protein phosphorylation by using improved Phos-tag Biotin.

Kinoshita, E. et al., Proteomics, 2012, 12, 932-937.

The IKK complex contributes to the induction of autophagy.

Criollo, A. et al., EMBO J., 2010, 293, 619-631.

Synergistic proapoptotic effects of the two tyrosine kinase inhibitors pazopanib and lapatinib on multiple carcinoma cell lines.

Olaussen, K. A. et al., Oncogene, 2009, 28, 4249–4260.

A substrate peptide for the FLT3 receptor tyrosine kinase.

Boehmer, F.-D. et al., Br. J. Haematol., 2009, 144, 127-130.

Analysis of EphA4 receptor tyrosine kinase substrate specificity using peptide-based arrays.

Warner, N. et al., FEBS J., 2008, 275, 2561-2573

A versatile strategy to define the phosphorylation preferences of plant protein kinases and screen for putative substrates.

Vlad, F. et al., Plant J., 2008, 55, 104-117

An amyloid beta vaccine that safely drives immunity to a key pathological species in Alzheimer’s disease: pyroglutamate amyloid beta

Vukicevic, M. et al., Brain Communications. 2022, 4, fcac022

Peptide microarrays coupled to machine learning reveal individual epitopes from human antibody responses with neutralizing capabilities against SARS-CoV-2

Hotop, SK. et al., Emerging Microbes & Infections. 2022, 11, 1037-1048

Cross-reactive antibodies against human coronaviruses and the animal coronavirome suggest diagnostics for future zoonotic spillovers

KLOMPUS, S. et al., SCIENCE IMMUNOLOGY. 2021, 6

A functional LSD1 coregulator screen reveals a novel transcriptional regulatory cascade connecting R-loop homeostasis with epigenetic regulation

Pinter, S. et al., Nucleic Acids Research. 2021, 49, 4350–4370

Comirnaty-Elicited and Convalescent Sera Recognize Different Spike Epitopes

Hein, S. et al., Vaccines. 2021, 9(12), 1419

Hydroxamic acid-modified peptide microarrays for profiling isozyme-selective interactions and inhibition of histone deacetylases

Moreno-Yruela, C. et al., Nat Commun. 2021, 12, 62

Persistence of infectious SARS-CoV-2 particles for up to 37 days in patients with mild COVID-19

Zahn, T. et al., Allergy. 2021

Analysis of BNT162b2- and CVnCoV-elicited sera and of convalescent sera toward SARS-CoV-2 viruses

Hein, S. et al., Allergy. 2021

From Patient to Pathways: An SH2-based Workflow for Studying Signaling in Chronic Lymphocytic Leukemia Using Biochemical and Computational Methods

Lafontaine, A. et al., 2020

Peptide Arrays: Development and Application

Szymczak et al., Anal Chem. 2018 January 02; 90(1): 266–282

The Mesenchymal Precursor Cell Marker Antibody STRO-1 Binds to Cell Surface Heat Shock Cognate 70

Fitter, S. et al., STEM CELLS. 2017, 35, 940-951

Application of dual reading domains as novel reagents in chromatin biology reveals a new H3K9me3 and H3K36me2/3 bivalent chromatin state

Mauser, R. et al., Epigenetics & Chromatin. 2017, 10,

Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission

Maric, H. M. et al., Nature chemical biology. 2016,

Highly homologous proteins exert opposite biological activities by using different interaction interfaces

Amir, A. I. et al., Scientific Reports. 2015, 5,

B cell epitopes on infliximab identified by oligopeptide microarray with unprocessed patient sera

Homann, A. et al., Journal of Translational Medicine. 2015, 13,

Identifying Protein-protein Interaction Sites Using Peptide Arrays

Amartely, H. et al., Journal of Visualized Experiments. 2014

Design of affinity peptides from natural protein ligands: A study of the cardiac troponin complex

Chandra, D. et al., Biopolymers. 2014, 102, 97-106

Development of Bispecific Molecules for the In Situ Detection of Protein-Protein Interactions and Protein Phosphorylation

van Dieck, J. et al., Chemistry & Biology. 2014, 21, 357-368

Secretion and Immunogenicity of the Meningioma-Associated Antigen TXNDC16

Harz, C. et al., The Journal of Immunology. 2014, 193, 3146-3154

Application of histone modification-specific interaction domains as an alternative to antibodies

Kungulovski, G. et al., Genome Research. 2014, 24, 1842-1853

ChIP-less analysis of chromatin states

Su, Z. et al., Epigenetics & chromatin. 2014, 7, 7

Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1

Tamir, S. et al., Proceedings of the National Academy of Sciences. 2014, 111, 5177-5182

Mapping of epitopes recognized by antibodies induced by immunization of mice with PspA and PspC.

Vadesilho, C. F. M. et al., Clin. Vaccine Immunol., 2014, 21, 940-948.

The scaffold protein MUPP1 regulates odorant-mediated signaling in olfactory sensory neurons.

Baumgart, S. et al., J. Cell Sci., 2014, 127, 2518-2527.

Structure–activity relationship studies using peptide arrays: the example of HIV-1 Rev–integrase interaction.

Gabizon, R. et al., Med. Chem. Commun., 2013, 4, 252-259.

Characterization of the translocation-competent complex between the Helicobacter pylori oncogenic protein CagA and the accessory protein CagF.

Bonsor, D. A. et al, J. Biol. Chem., 2013, 288, 32897-32909.

Mapping the Vif–A3G interaction using peptide arrays: A basis for anti-HIV lead peptides.

Reingewertz, T. H. et al., Bioorg. Med. Chem., 2013, 21, 3523-3532.

Peptide Arrays for Development of PDGFRβ Affine Molecules.

Marr, A. et al., Mol. Imaging Biol., 2013, 15, 391-400.

Design of peptide affinity ligands for S-protein: a comparison of combinatorial and de novo design strategies

Chandra, D. et al., Molecular Diversity. 2013, 17, 357-369

Highly sensitive detection of protein phosphorylation by using improved Phos-tag Biotin.

Kinoshita, E. et al., Proteomics, 2012, 12, 932-937.

Lamin B receptor recognizes specific modifications of histone H4 in heterochromatin formation.

Hirano, Y. et al., J. Biol. Chem.,2012, 287, 42654-42663.

The SET8 H4K20 protein lysine methyltransferase has a long recognition sequence covering seven amino acid residues.

Kudithipudi, S. et al., Biochemie, 2012, 94, 2212-2218.

Multivalent Recognition of Histone Tails by the PHD Fingers of CHD5.

Oliver, S. S. et al., Biochemistry, 2012, 51, 6534-6544.

Molecular Basis of the Interaction between Proapoptotic Truncated BID (tBID) Protein and Mitochondrial Carrier Homologue 2 (MTCH2) Protein: Key Players in Mitochondrial Pathway.

Katz, C. et al., J. Biol. Chem., 2012, 287, 15016-15023.

TheTomato yellow leaf curl virus(TYLCV) V2 protein interacts with the host papain-like cysteine protease CYP1

Bar-Ziv, A. et al., Plant Signaling & Behavior. 2012, 7, 983-989

Probing subunit-subunit interactions in the yeast vacuolar ATPase by peptide arrays

Parsons, L. S. et al., PloS one. 2012, 7, e46960

Secreted Kinase Phosphorylates Extracellular Proteins That Regulate Biomineralization

Tagliabracci, V. S. et al., Science. 2012, 336, 1150-1153

Detailed specificity analysis of antibodies binding to modified histone tails with peptide arrays.

Bock, I. et al., Epigenetics, 2011, 6, 256-263

Stomatal Closure by Fast Abscisic Acid Signaling Is Mediated by the Guard Cell Anion Channel SLAH3 and the Receptor RCAR1.

Geiger, D. et al., Sci. Signal, 2011, 4, ra32

The ATRX-ADD domain binds to H3 tail peptides and reads the combined methylation state of K4 and K9.

Dhayalan, A. et al., Hum. Mol. Genet., 2011, 20, 2195-2203

Voltage-dependent anion channel 1-based peptides interact with Bcl-2 to prevent antiapoptotic activity.

Arbel, N. et al., J. Biol. Chem., 2010, 285, 6053-6062

The IKK complex contributes to the induction of autophagy.

Criollo, A. et al., EMBO J., 2010, 293, 619-631

Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail.

Zhang, Y. et al; Nucleic Acids Res., 2010, 38, 4246-4253

Synergistic proapoptotic effects of the two tyrosine kinase inhibitors pazopanib and lapatinib on multiple carcinoma cell lines.

Olaussen, K. A. et al., Oncogene, 2009, 28, 4249–4260

A substrate peptide for the FLT3 receptor tyrosine kinase.

Boehmer, F.-D. et al., Br. J. Haematol., 2009, 144, 127-130

Modulation of cell spreading and cell-substrate adhesion dynamics by dystroglycan

Thompson, O. et al., Journal of Cell Science. 2009, 123, 118-127

Olfactory receptor signaling is regulated by the post-synaptic density 95, Drosophila discs large, zona-occludens 1 PDZ scaffold multi-PDZ domain protein 1.

Dooley, R. et al., FEBS J., 2009, 276, 7279-7290

Activity of guard cell anion channel SLAC1 is controlled by drought-stress signaling kinase-phosphatase pair.

Geiger, D. et al., Proc. Natl. Acad. Sci. USA, 2009, 106, 21425-21430.

Defining the specificity space of the human SRC homology 2 domain.

Huang, H. et al., Mol. Cell Proteomics, 2008, 74, 768-784

Analysis of EphA4 receptor tyrosine kinase substrate specificity using peptide-based arrays.

Warner, N. et al., FEBS J., 2008, 275, 2561-2573

Molecular basis of the interaction between the antiapoptotic Bcl-2 family proteins and the proapoptotic protein ASPP2.

Katz, C. et al., Proc. Natl. Acad. Sci. USA, 2008, 105, 12277-12282

Effective rational humanization of a PASylated anti-galectin-3 Fab for the sensitive PET imaging of thyroid cancer in vivo

Peplau, E. et al., Sci Rep. 2021, 11, 7358

Mapping of domain-mediated protein-protein interaction by SPOT peptide assay

Mao, X. et al., STAR Protocols. 2021, 2, 100503

CaMKK2 facilitates Golgi-associated vesicle trafficking to sustain cancer cell proliferation

Stewart, L.M. et al., Cell Death Dis. 2021, 12, 1040

Phospho-regulation of the Shugoshin – Condensin interaction at the centromere in budding yeast

Yahya, G. et al., PLoS Genet. 2020, 16(8), e1008569

HACS1 signaling adaptor protein recognizes a motif in the paired immunoglobulin receptor B cytoplasmic domain

Kwan, J.J. et al., Communications Biology. 2020, 3, Article number: 672

Recognition of nonproline N-terminal residues by the Pro/N-degron pathway

Dong, C. et al., PNAS. 2020, 117 (25), 14158-14167

Synaptic zinc inhibition of NMDA receptors depends on the association of GluN2A with the zinc transporter ZnT1

KRALL, RF. et al., SCIENCE ADVANCES. 2020, 6, No. 27

Modulating the rate of fibrin formation and clot structure attenuates microvascular thrombosis in systemic inflammation

Valladolid, C. et al., Blood Adv. 2020, 4(7), 1340–1349

Mitochondrial ClpX activates an essential biosynthetic enzyme through partial unfolding

Kardon, JR. et al., eLife. 2020, 9, e54387

The highly GABARAP specific rat monoclonal antibody 8H5 visualizes GABARAP in immunofluorescence imaging at endogenous level

Simons, I.M. et al., Sci Rep. 2019, 9, 526

Small Peptide Ligands for Targeting EGFR in Triple Negative Breast Cancer Cells

Hossein-Nejad-Ariani, H. et al., Sci Rep. 2019, 9, 2723

PEPOP 2.0: new approaches to mimic non-continuous epitopes

Demolombe, V. et al., BMC Bioinformatics. 2019, 20, 387

Endothelial PKA activity regulates angiogenesis by limiting autophagy through phosphorylation of ATG16L1

Zhao, X. et al., eLife. 2019, 8, e46380

Mammalian Atg8 proteins regulate lysosome and autolysosome biogenesis through SNAREs

Gu, Y. et al., The EMBO Journal. 2019, 38, e101994

Proline-Rich Peptides with Improved Antimicrobial Activity against E. coli, K. pneumoniae, and A. baumannii

Dr. Mardirossian, M. et al., ChemMedChem. 2019, 14, 2025-2033

Screening and optimizing ontimicrobial Peptides by using SPOT-Synthesis

López-pérez P. M. et al., Front. Chem., 2017, 5

Investigation of the network of preferred interactions in an artificial coiled-coil association using the peptide array technique

Araghi, R. R. et al., Beilstein Journal of Organic Chemistry. 2012, 8, 640-649

Synthetic peptide arrays for investigating protein interaction domains

Volkmer, R. et al., FEBS Letters. 2012, 586, 2780-2786

The Plk1-dependent phosphoproteome of the early mitotic spindle.

Santamaria, A. et al., Mol. Cell Proteomics, 2011, 10, M110.004457

Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation.

Zegerman, P. and Diffley, J. F. X., Nature, 2010, 467, 474-478

Identification of High-Affinity PB1-Derived Peptides with Enhanced Affinity to the PA Protein of Influenza A Virus Polymerase

Wunderlich, K. et al., Antimicrobial Agents and Chemotherapy. 2010, 55, 696-702

Peptide Microarrays: Methods and Protocols

Cretich, M., & Chiari, M. Springer, 2009

Synthesis and Application of Peptide Arrays: Quo Vadis SPOT Technology

Volkmer, R., ChemBioChem. 2009, 10, 1431-1442

Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase.

Kiely, P. A. et al., J. Biol. Chem., 2009, 284, 20263-20274

Peptide arrays on cellulose support: SPOT synthesis, a time and cost efficient method for synthesis of large numbers of peptides in a parallel and addressable fashion.

Hilpert, K. et al., Nature Protocols, 2, 2007, ,1333-1349.

Cellulose-bound peptide arrays: preparation and applications

Hilpert, K. et al., Biotechnology and Genetic Engineering Reviews. 2007, 24, 31-106

Using peptide arrays to define nuclear carrier binding sites on nucleoporins

Cushman, I. et al., Methods. 2006, 39, 329-341

Analysis of Protein Interactions with Immobilized Peptide Arrays Synthesized on Membrane Supports

Frank, R. et al., Cold Spring Harbor Protocols. 2006, pdb.prot4566-pdb.prot456

Applying the SPOT peptide synthesis procedure to the study of protein tyrosine phosphatase substrate specificity: probing for the heavenly match in vitro

ESPANEL, X. et al., Methods. 2005, 35, 64-72

Kombinatorische SPOT-Synthese neuer S-Glycopeptide als Oligosaccharidmimikry zur Untersuchung von Kohlenhydrat-Protein-Wechselwirkungen

Schips, C., 2005

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Spot synthesis: an easy technique for the positionally addressable, parallel chemical synthesis on a membrane support.

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The simultaneous multiple production of solution phase peptides; assessment of the Geysen Method of simultaneous peptide synthesis.

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WALTZ-DB 2.0: an updated database containing structural information of experimentally determined amyloid-forming peptides

Louros, K. et al., Nucleic Acids Research. 2020, 48, D389–D393

Thiol-to-amine cyclization reaction enables screening of large libraries of macrocyclic compounds and the generation of sub-kilodalton ligands

KALE, S.S. et al., Science. 2019, 5

Identification of short terminal motifs enriched by antibodies using peptide mass fingerprinting.

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A large synthetic peptide and phosphopeptide reference library for mass spectrometry–based proteomics.

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Parallel synthesis and splicing redirection activity of cell-penetrating peptide conjugate libraries of a PNA cargo.

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The SH2 Domain Interaction Landscape.

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Natural immunity to pluripotency antigen OCT4 in humans.

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The phosphotyrosine interactome of the insulin receptor family and its substrates IRS-1 and IRS-2.

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A versatile strategy to define the phosphorylation preferences of plant protein kinases and screen for putative substrates.

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Probing the substrate specificity of the dengue virus type 2 NS3 serine protease by using internally quenched fluorescent peptides.

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Biselectivity of isoDGR Peptides for Fibronectin Binding Integrin Subtypes α5β1 and αvβ6: Conformational Control through Flanking Amino Acids.

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A Periodate-Cleavable Linker for Functional Proteomics under Slightly Acidic Conditions: Application for the Analysis of Intracellular Aspartic Proteases.

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Interface Immobilization Chemistry of cRGD‐based Peptides Regulates Integrin Mediated Cell Adhesion.

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Ethyl substituted coumarin-4-yl derivatives as photoremovable protecting groups for amino acids with improved stability for SPPS.

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Guiding plant virus particles to integrin-displaying cells.

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CyLoP-1: A Novel Cysteine-Rich Cell-Penetrating Peptide for Cytosolic Delivery of Cargoes.

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In situ assembly of macromolecular complexes triggered by light.

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Improving Oral Bioavailability of Peptides by Multiple N-Methylation: Somatostatin Analogues.

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Conformational Preference and Potential Templates of N-Methylated Cyclic Pentaalanine Peptides.

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Titanium dioxide as a chemo-affinity solid phase in offline phosphopeptide chromatography prior to HPLC-MS/MS analysis.

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Multimeric Cyclic RGD Peptides as Potential Tools for Tumor Targeting: Solid-Phase Peptide Synthesis and Chemoselective Oxime Ligation.

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Glycosylated RGD-Containing Peptides: Tracer for Tumor Targeting and Angiogenesis Imaging with Improved Biokinetics.

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An efficient Fmoc strategy for the rapid synthesis of peptide para-nitroanilides.

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Combined solid phase and solution synthesis of the fully protected segment 74-99 of HIV 1-protease with the application of a new trityl-linker.

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